Publications

Publications 2024

Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury. Heller K, Flocke V, Straub T, Ding Z, Srivastava T, Nowak M, Funk F, Levkau B, Schmitt J, Grandoch M & Flögel U. npj Imaging 2, 36 (2024). doi: 10.1038/s44303-024-00044-0 

Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance. Springer C, Binsch C, Weide D, Toska L, Cremer AL, Backes H, Scheel AK, Espelage L, Kotzka J, Sill S, Kurowski A, Kim D, Karpinski S, Schnurr TM, Hansen T, Hartwig S, Lehr S, Cames S, Brüning JC, Lienhard M, Herwig R, Börno S, Timmermann B, Al-Hasani H, Chadt A. Diabetes. 2024 Jul 1;73(7):1058-1071. doi: 10.2337/db23-0463. PMID: 38608276.

Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis. Eberhard D*, Balkenhol S*, Köster A, Follert P, Upschulte E, Ostermann P, Kirschner P, Uhlemeyer C, Charnay I, Preuss C, Trenkamp S, Belgardt B-F, Dickscheid T, Esposito I, Roden M, Lammert E. Nat Cardiovasc Res. 2024 June 3:734-753, doi.org/10.1038/s44161-024-00487-z , *equally contributed

The N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan Improves Glucose Homeostasis and Preserves Pancreatic Islets in NOD Mice. Wörmeyer L, Nortmann O, Hamacher A, Uhlemeyer C, Belgardt B, Eberhard D, Mayatepek E, Meissner T, Lammert E, Welters A. Horm Metab Res. 2024 Mar;56(3):223-234. doi: 10.1055/a-2236-8625. Epub 2024 Jan 2. PMID: 38168730; PMCID: PMC10901624.

Post mortem analysis of hepatic volume and lipid content by magnetic resonance imaging and spectroscopy in fixed murine neonates.  Jonuscheit M*, Uhlemeyer C*, Korzekwa B, Schouwink M, Öner-Sieben S, Ensenauer R, Roden M, Belgardt BF, Schrauwen-Hinderling VB. NMR Biomed. 2024 Mar 31:e5140. doi: 10.1002/nbm.5140. Epub ahead of print. PMID: 38556731. *equally contributed

Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes. Große-Segerath L, Follert P, Behnke K, Ettich J, Buschmann T, Kirschner P, Hartwig S, Lehr S, Korf-Klingebiel M, Eberhard D, Lehwald-Tywuschik N, Al-Hasani H, Knoefel WT, Heinrich S, Levkau B, Wollert KC, Scheller J, Lammert E. Nat Commun. 2024 Feb 5;15(1):1076. doi: 10.1038/s41467-024-44760-y. PMID: 38316785; PMCID: PMC10844291.

AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle.  Peifer-Weiß L, Al-Hasani H, Chadt A. Int J Mol Sci. 2024 Feb 5;25(3):1910. doi: 10.3390/ijms25031910. PMID: 38339185; PMCID: PMC10855711.
 

Publications 2023

A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes.  Peifer-Weiß L, Kurban M, David C, Lubeck M, Kondadi AK, Nemer G, Reichert AS, Anand R. Clin Genet. 2023 Dec;104(6):659-668. doi: 10.1111/cge.14420. Epub 2023 Aug 30. PMID: 37649161.

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95. Minafra AR, Rafii P, Mossner S, Bazgir F, Floss DM, Moll JM, Scheller J. J Biol Chem. 2023 Aug;299(8):104989. doi: 10.1016/j.jbc.2023.104989. Epub 2023 Jun 29. PMID: 37392849; PMCID: PMC10413154.

The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells. Jochims F, Strohm R, von Montfort C, Wenzel CK, Klahm N, Kondadi AK, Stahl W, Reichert AS, Brenneisen P. Biomedicines. 2023 Aug 27;11(9):2393. doi: 10.3390/biomedicines11092393. PMID: 37760834; PMCID: PMC10525565.

Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine. Jiang L, Piribauer M, Kostov T, Steidel S, Bizjak DA, Steinacker JM, Parr M, Diel P. Toxicol Lett. 2023 Aug 15;385:21-28. doi: 10.1016/j.toxlet.2023.08.007. Epub 2023 Aug 19. PMID: 37598871.

Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence. Averdunk L, Huetzen MA, Moreno-Andrés D, Kalb R, McKee S, Hsieh TC, Seibt A, Schouwink M, Lalani S, Faqeih EA, Brunet T, Boor P, Neveling K, Hoischen A, Hildebrandt B, Graf E, Lu L, Jin W, Schaper J, Omer JA, Demaret T, Fleischer N, Schindler D, Krawitz P, Mayatepek E, Wieczorek D, Wang LL, Antonin W, Jachimowicz RD, von Felbert V, Distelmaier F. Genet Med. 2023 Jul;25(7):100836. doi: 10.1016/j.gim.2023.100836. Epub 2023 Mar 31. PMID: 37013901.

MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins. Lubeck M, Derkum NH, Naha R, Strohm R, Driessen MD, Belgardt BF, Roden M, Stühler K, Anand R, Reichert AS, Kondadi AK. PLoS One. 2023 Jun 6;18(6):e0286756. doi: 10.1371/journal.pone.0286756. PMID: 37279200; PMCID: PMC10243636.

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism. Pelligra A, Mrugala J, Griess K, Kirschner P, Nortmann O, Bartosinska B, Köster A, Krupenko NI, Gebel D, Westhoff P, Steckel B, Eberhard D, Herebian D, Belgardt BF, Schrader J, Weber APM, Krupenko SA, Lammert E. Cell Rep. 2023 Jun 22;42(7):112703. doi: 10.1016/j.celrep.2023.112703. Epub ahead of print. Erratum for: Cell Rep. 2023 Jun 7;42(6):112615. PMID: 37352100.

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy. Beziaud L, Young CM, Alonso AM, Norkin M, Minafra AR, Huelsken J. Cell Stem Cell. 2023 Jun 1;30(6):818-831.e6. doi: 10.1016/j.stem.2023.05.007. PMID: 37267916.

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes. Rafii P, Seibel C, Weitz HT, Ettich J, Minafra AR, Petzsch P, Lang A, Floss DM, Behnke K, Köhrer K, Moll JM, Scheller J. Commun Biol. 2023 Apr 15;6(1):418. doi: 10.1038/s42003-023-04768-4. PMID: 37061565; PMCID: PMC10105715.

Combinatory in vitro effects of the β2-agonists salbutamol and formoterol in skeletal muscle cells. Piribauer M, Jiang L, Kostov T, Parr M, Steidel S, Bizjak DA, Steinacker JM, Diel P. Toxicol Lett. 2023 Apr 1;378:10-18. doi: 10.1016/j.toxlet.2023.02.007. Epub 2023 Feb 21. PMID: 36822333.

Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus. Uhlemeyer C, Müller N, Rieck M, Kuboth J, Schlegel C, Grieß K, Dorweiler TF, Heiduschka S, Eckel J, Roden M, Lammert E, Stoffel M, Belgardt BF. Mol Metab. 2023 Jan;67:101650. doi: 10.1016/j.molmet.2022.101650. Epub 2022 Dec 5. PMID: 36470401

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. Nat Cell Biol. 2023 Jan;25(1):20-29. doi: 10.1038/s41556-022-01027-2. Epub 2022 Dec 21. PMID: 36543979; PMCID: PMC9859757.

E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice. Altenhofen D, Khuong JM, Kuhn T, Lebek S, Görigk S, Kaiser K, Binsch C, Griess K, Knebel B, Belgardt BF, Cames S, Eickelschulte S, Stermann T, Rasche A, Herwig R, Weiss J, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Int J Mol Sci. 2023 Jan 3;24(1):845. doi: 10.3390/ijms24010845. PMID: 36614300; PMCID: PMC9820861.

Secretome analysis of murine insulin resistant skeletal muscle cells after EPS treatment. Pottgießer MF, Deatc MI, Förster PM, Hartwig S, Lehr S, Chadt A, Al-Hasani H. Diabetologie und Stoffwechsel 2023; 18(S01):20-20 doi: 10.1055/s-0043-1767878

Publications 2022

Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. Pafili K, Kahl S, Mastrototaro L, Strassburger K, Pesta D, Herder C, Pützer J, Dewidar B, Hendlinger M, Granata C, Saatmann N, Yavas A, Gancheva S, Heilmann G, Esposito I, Schlensak M, Roden M. Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. J Hepatol. 2022 Dec;77(6):1504-1514. doi: 10.1016/j.jhep.2022.08.010. Epub 2022 Aug 19. PMID: 35988689.

Diabetes disturbs functional adaptation of the remote myocardium after ischemia/reperfusion. Funk F, Kronenbitter A, Isić M, Flocke V, Gorreßen S, Semmler D, Brinkmann M, Beck K, Steinhoff O, Srivastava T, Barbosa DM, Voigt K, Wang L, Bottermann K, Kötter S, Grandoch M, Flögel U, Krüger M, Schmitt JP. J Mol Cell Cardiol. 2022 Dec;173:47-60. doi: 10.1016/j.yjmcc.2022.09.002. Epub 2022 Sep 21. PMID: 36150524.

Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene. Kuhn T, Kaiser K, Lebek S, Altenhofen D, Knebel B, Herwig R, Rasche A, Pelligra A, Görigk S, Khuong JM, Vogel H, Schürmann A, Blüher M, Chadt A, Al-Hasani H. Hum Mol Genet. 2022 Nov 28;31(23):4019-4033. doi: 10.1093/hmg/ddac150. PMID: 35796564; PMCID: PMC9703946.

Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise. Minafra AR, Chadt A, Rafii P, Al-Hasani H, Behnke K and Scheller J. Front. Endocrinol. 2022 Oct 27:1028808. doi: 10.3389/fendo.2022.1028808

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes. Görigk S, Ouwens DM, Kuhn T, Altenhofen D, Binsch C, Damen M, Khuong JM, Kaiser K, Knebel B, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159153. doi: 10.1016/j.bbalip.2022.159153. Epub 2022 Mar 31.

Many ways to Rome: Exercise, cold exposure and diet – Do they all affect BAT activation and WAT browning in the same manner?
Scheel A, Espelage L, Chadt A. International Journal of Molecular Sciences. Review Article. 2022 Apr 26;23(9):4759. doi: 10.3390/ijms23094759. PMID:35563150; PMCID: PMC9103087.

Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells. Franchina DG, Kurniawan H, Grusdat M, Binsfeld C, Guerra L, Bonetti L, Soriano-Baguet L, Ewen A, Kobayashi T, Farinelle S, Minafra AR, Vandamme N, Carpentier A, Borgmann FK, Jäger C, Chen Y, Kleinewietfeld M, Vasiliou V, Mittelbronn M, Hiller K, Lang PA, Brenner D. Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells. Nat Commun. 2022 Apr 4;13(1):1789. doi: 10.1038/s41467-022-29426-x. PMID: 35379825; PMCID: PMC8980022.

Publications 2021

Contraction-Mediated Glucose Transport in Skeletal Muscle is Regulated by a Framework of AMPK, TBC1D1/4 and Rac1. de Wendt C, Espelage L, Eickelschulte S, Springer C, Toska L, Scheel A, Bedou AD, Benninghoff T, Cames S, Stermann T, Chadt A, Al-Hasani H. Diabetes. 2021 Sep 24:db210587. doi: 10.2337/db21-0587. Online ahead of print.PMID: 34561225

Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes. Urbach J, Kondadi AK, David C, Naha R, Deinert K, Reichert AS, Anand R. Biochim Biophys Acta Biomembr. 2021 Dec 1;1863(12):183683. doi: 10.1016/j.bbamem.2021.183683. Epub 2021 Jul 13. PMID: 34271005.

Mitochondrial DNA copy number variation - A potential biomarker for early onset preeclampsia. Pandey D, Yevale A, Naha R, Kuthethur R, Chakrabarty S, Satyamoorthy K. Pregnancy Hypertens. 2021 Mar;23:1-4. doi: 10.1016/j.preghy.2020.10.002. Epub 2020 Oct 12. PMID: 33160129.

Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection. Chaudhari S, Dey Pereira S, Asare-Warehene M, Naha R, Kabekkodu SP, Tsang BK, Satyamoorthy K. J Ovarian Res. 2021 Feb 25;14(1):39. doi: 10.1186/s13048-021-00787-z. PMID: 33632295; PMCID: PMC7906086.
 

Publications 2020

Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy. Naha R, Anees A, Chakrabarty S, Naik PS, Pandove M, Pandey D, Satyamoorthy K. Mitochondrion. 2020 Nov;55:85-94. doi: 10.1016/j.mito.2020.08.008. Epub 2020 Aug 28. PMID: 32861875

The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4. Benninghoff T, Espelage L, Eickelschulte S, Zeinert I, Sinowenka I, Müller F, Schöndeling C, Batchelor H, Cames S, Zhou Z, Kotzka J, Chadt A, Al-Hasani H. Diabetes. 2020 Nov;69(11):2281-2293. doi: 10.2337/db20-0180. Epub 2020 Aug 31. PMID: 32868338.

DINAX- a comprehensive database of inherited ataxias. Chaudhari S, Naha R, Mukherjee S, Sharma A, Jayaram P, Mallya S, Chakrabarty S, Satyamoorthy K. Comput Biol Med. 2020 Nov;126:104000. doi: 10.1016/j.compbiomed.2020.104000. Epub 2020 Sep 17. PMID: 33007622
 

Archive / not peer-reviewed

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways. Lubeck M, Naha R, Schaumkessel S, Westhoff ., Stefanski A, Petzsch P, Stühler K, Köhrer K, Weber APM, Anand R, Reichert AS, Kondadi AK.  bioRxiv. Preprint 2023 Dec 3, https://doi.org/10.1101/2023.12.01.569567.

MIC13 and SLP2 seed the Assembly of mic60-subcomplex to facilitate Crista Junction Formation. Naha R, Strohm R, Urbach J, Wittig I, Reichert AS, Kondadi AK, & Anand R. bioRxiv. Preprint 2023 Nov 3. https://www.biorxiv.org/content/10.1101/2023.09.04.556207v2

Publications 2024

Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes. Kovac L, Gancheva S, Jähnert M, Sehgal R, Mastrototaro L, Schlensak M, Granderath FA, Rittig K, Roden M, Schürmann A, Kahl S, Ouni M. Diabetes Metab. 2024 Sep;50(5):101561. doi: 10.1016/j.diabet.2024.101561. Epub 2024 Jul 6. PMID: 38977261

Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity. Kahl S, Straßburger K, Pacini G, Trinks N, Pafili K, Mastrototaro L, Dewidar B, Sarabhai T, Trenkamp S, Esposito I, Schlensak M, Granderath FA, Roden M. J Hepatol. 2024 Aug 30:S0168-8278(24)02490-5. doi: 10.1016/j.jhep.2024.08.012. Epub ahead of print. PMID: 39218222

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, López-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Böddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kühn R, Wanker EE, Priller J, Metzger JJ, Prigione A. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PMID: 39174523; PMCID: PMC11341898

The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes. Mastrototaro L, Roden M. Proteomics. 2024 Jun;24(11):e2300078. doi: 10.1002/pmic.202300078. Epub 2023 Jul 31. PMID: 37525338

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity. Dietzsch AN, Al-Hasani H, Altschmied J, Bottermann K, Brendler J, Haendeler J, Horn S, Kaczmarek I, Körner A, Krause K, Landgraf K, Le Duc D, Lehmann L, Lehr S, Pick S, Ricken A, Schnorr R, Schulz A, Strnadová M, Velluva A, Zabri H, Schöneberg T, Thor D, Prömel S. Signal Transduct Target Ther. 2024 Apr 26;9(1):103. doi: 10.1038/s41392-024-01810-7. PMID: 38664368; PMCID: PMC11045723

Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Petersilie L, Heiduschka S, Nelson JSE, Neu LA, Le S, Anand R, Kafitz KW, Prigione A, Rose CR. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. PMID: 38523789; PMCID: PMC10957451

Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease. Sarabhai T, Kahl S, Gancheva S, Mastrototaro L, Dewidar B, Pesta D, Ratter-Rieck JM, Bobrov P, Jeruschke K, Esposito I, Schlensak M, Roden M. Metabolism. 2024 Feb;151:155762. doi: 10.1016/j.metabol.2023.155762. Epub 2023 Dec 19. PMID: 38122893.

Mitochondrial Dynamics at Different Levels: From Cristae Dynamics to Interorganellar Cross Talk. Kondadi AK, Reichert AS. Annu Rev Biophys. 2024 Jan 2. doi: 10.1146/annurev-biophys-030822-020736. Epub ahead of print. PMID: 38166176.

Publications 2023

Cristae dynamics is modulated in bioenergetically compromised mitochondria. Golombek M, Tsigaras T, Schaumkessel Y, Hänsch S, Weidtkamp-Peters S, Anand R, Reichert AS, Kondadi AK. Life Sci Alliance. 2023 Nov 13;7(2):e202302386. doi: 10.26508/lsa.202302386. PMID: 37957016; PMCID: PMC10643176.

NECAB2 is an endosomal protein important for striatal function. Bueno D, Narayan Dey P, Schacht T, Wolf C, Wüllner V, Morpurgo E, Rojas-Charry L, Sessinghaus L, Leukel P, Sommer C, Radyushkin K, Florin L, Baumgart J, Stamm P, Daiber A, Horta G, Nardi L, Vasic V, Schmeisser MJ, Hellwig A, Oskamp A, Bauer A, Anand R, Reichert AS, Ritz S, Nocera G, Jacob C, Peper J, Silies M, Frauenknecht KBM, Schäfer MKE, Methner A. Free Radic Biol Med. 2023 Nov 1;208:643-656. doi: 10.1016/j.freeradbiomed.2023.09.003. Epub 2023 Sep 16. PMID: 37722569.

Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M. EBioMedicine. 2023 Aug;94:104714. doi: 10.1016/j.ebiom.2023.104714. Epub 2023 Jul 16. PMID: 37454552; PMCID: PMC10384226.

The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes. Mastrototaro L, Roden M. Proteomics. 2023 Jul 31:e2300078. doi: 10.1002/pmic.202300078. Epub ahead of print. PMID: 37525338.

Involvement of necroptosis in the selective toxicity of the natural compound (±) gossypol on squamous skin cancer cells in vitro. Haasler L, von Montfort C, Kondadi AK, Golombek M, Ebbert L, Wenzel CK, Stahl W, Reichert AS, Brenneisen P. Arch Toxicol. 2023 Jul;97(7):1997-2014. doi: 10.1007/s00204-023-03516-1. Epub 2023 May 21. PMID: 37210688; PMCID: PMC10256661.

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR. Commun Biol. 2023 Jun 21;6(1):657. doi: 10.1038/s42003-023-05013-8. PMID: 37344639; PMCID: PMC10284840.

NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems. Molinari PE, Krapp AR, Weiner A, Beyer HM, Kondadi AK, Blomeier T, López M, Bustos-Sanmamed P, Tevere E, Weber W, Reichert AS, Calcaterra NB, Beller M, Carrillo N, Zurbriggen MD. Nat Commun. 2023 Jun 6;14(1):3277. doi: 10.1038/s41467-023-38739-4. PMID: 37280202; PMCID: PMC10244373.

The impact of mild hypoxia exposure on myokine secretion in human obesity.  van Meijel RLJ, Vliex LMM, Hartwig S, Lehr S, Al-Hasani H, Blaak EE, Goossens GH. Int J Obes (Lond). 2023 Mar 30. doi: 10.1038/s41366-023-01294-5. Epub ahead of print. PMID: 36997723.

Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo- controlled crossover trial. Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M. Diabetologia. 2023 Jan;66(1):57-69. doi: 10.1007/s00125-022-05797-0. Epub 2022 Sep 30. PMID: 36178534; PMCID: PMC9729133.

Publications 2022

Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. Piroth M, Gorski DJ, Hundhausen C, Petz A, Gorressen S, Semmler D, Zabri H, Hartwig S, Lehr S, Kelm M, Jung C, Fischer JW. Matrix Biol. 2022 Sep;112:116-131. doi: 10.1016/j.matbio.2022.08.008. Epub 2022 Aug 23. PMID: 35998871.

Adaptation of Oxidative Phosphorylation Machinery Compensates for Hepatic Lipotoxicity in Early Stages of MAFLD.  Fahlbusch P, Nikolic A, Hartwig S, Jacob S, Kettel U, Köllmer C, Al-Hasani H, Lehr S, Müller-Wieland D, Knebel B, Kotzka J. Int J Mol Sci. 2022 Jun 20;23(12):6873. doi: 10.3390/ijms23126873. PMID: 35743314; PMCID: PMC9224893.

Author Correction: Dynamic changes of muscle insulin sensitivity after metabolic surgery. Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M. Nat Commun. 2022 Jun 10;13(1):3353. doi: 10.1038/s41467-022-29350-0. Erratum for: Nat Commun. 2019 Sep 13;10(1):4179. PMID: 35688803; PMCID: PMC9187703.

Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M. Pharmacol Res. 2022 May;179:106193. doi: 10.1016/j.phrs.2022.106193. Epub 2022 Mar 28. PMID: 35358682.

Impaired Hepatic Mitochondrial Capacity in Nonalcoholic Steatohepatitis Associated With Type 2 Diabetes. Gancheva S, Kahl S, Pesta D, Mastrototaro L, Dewidar B, Strassburger K, Sabah E, Esposito I, Weiß J, Sarabhai T, Wolkersdorfer M, Fleming T, Nawroth P, Zimmermann M, Reichert AS, Schlensak M, Roden M. Diabetes Care. 2022 Apr 1;45(4):928-937. doi: 10.2337/dc21-1758. PMID: 35113139.

Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Sarabhai T, Koliaki C, Mastrototaro L, Kahl S, Pesta D, Apostolopoulou M, Wolkersdorfer M, Bönner AC, Bobrov P, Markgraf DF, Herder C, Roden M. Diabetologia. 2022 Feb;65(2):301-314. doi: 10.1007/s00125-021-05596-z. Epub 2021 Oct 26. PMID: 34704121; PMCID: PMC8741704.

Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21. Dille M, Nikolic A, Wahlers N, Fahlbusch P, Jacob S, Hartwig S, Lehr S, Kabra D, Klymenko O, Al-Hasani H, Kotzka J, Knebel B. Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1;1868(1):166286. doi: 10.1016/j.bbadis.2021.166286. Epub 2021 Oct 6. PMID: 34624498.

Publications 2021

Insulin resistance and insulin sensitizing agents. Mastrototaro L, Roden M. Metabolism. 2021 Dec;125:154892. doi: 10.1016/j.metabol.2021.154892. Epub 2021 Sep 23. PMID: 34563556.

Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M. Sci Adv. 2021 Oct 8;7(41):eabi9551. doi: 10.1126/sciadv.abi9551. Epub 2021 Oct 8. PMID: 34623918; PMCID: PMC8500512.

Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis. Anand R, Reichert AS, Kondadi AK. Biology (Basel). 2021 Jun 29;10(7):600. doi: 10.3390/biology10070600. PMID: 34209580; PMCID: PMC8301002.

High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol. Deitersen J, Berning L, Stuhldreier F, Ceccacci S, Schlütermann D, Friedrich A, Wu W, Sun Y, Böhler P, Berleth N, Mendiburo MJ, Seggewiß S, Anand R, Reichert AS, Monti MC, Proksch P, Stork B. Cell Death Dis. 2021 May 31;12(6):560. doi: 10.1038/s41419-021-03830-5. PMID: 34059630; PMCID: PMC8167120.

The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro. Haasler L, Kondadi AK, Tsigaras T, von Montfort C, Graf P, Stahl W, Brenneisen P. Arch Toxicol. 2021 Apr;95(4):1349-1365. doi: 10.1007/s00204-021-02987-4. Epub 2021 Feb 1. PMID: 33523262; PMCID: PMC8032633.

The relevance of mitochondrial morphology for human disease. Navaratnarajah T, Anand R, Reichert AS, Distelmaier F. Int J Biochem Cell Biol. 2021 May;134:105951. doi: 10.1016/j.biocel.2021.105951. Epub 2021 Feb 18. PMID: 33610749.

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex. Viana MP, Levytskyy RM, Anand R, Reichert AS, Khalimonchuk O. iScience. 2021 Jan 29;24(2):102119. doi: 10.1016/j.isci.2021.102119. PMID: 33644718; PMCID: PMC7892988.

Preparation of "Functional" Mitochondria: A Challenging Business. Lehr S, Hartwig S, Kotzka J. Methods Mol Biol. 2021;2276:31-39. doi: 10.1007/978-1-0716-1266-8_2. PMID: 34060030.

Isolation and Quality Control of Functional Mitochondria. Hartwig S, Kotzka J, Lehr S. Methods Mol Biol. 2021;2276:41-55. doi: 10.1007/978-1-0716-1266-8_3. PMID: 34060031.

Methods for Proteomics-Based Analysis of the Human Muscle Secretome Using an In Vitro Exercise Model. Weigert C, Hartwig S, Lehr S. Methods Mol Biol. 2021;2261:433-442. doi: 10.1007/978-1-0716-1186-9_27. PMID: 33421006.

Publications 2020

Cristae Membrane Dynamics - A Paradigm Change. Kondadi AK, Anand R, Reichert AS. Trends Cell Biol. 2020 Dec;30(12):923-936. doi: 10.1016/j.tcb.2020.08.008. Epub 2020 Sep 23. PMID: 32978040.

Cardiometabolic risk factor clustering in patients with deficient branched-chain amino acid catabolism: A case-control study. Gancheva S, Caspari D, Bierwagen A, Jelenik T, Caprio S, Santoro N, Rothe M, Markgraf DF, Herebian D, Hwang JH, Öner-Sieben S, Mennenga J, Pacini G, Thimm E, Schlune A, Meissner T, Vom Dahl S, Klee D, Mayatepek E, Roden M, Ensenauer R. J Inherit Metab Dis. 2020 Sep;43(5):981-993. doi: 10.1002/jimd.12231. Epub 2020 Apr 6. PMID: 32118306.

MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes. Anand R, Kondadi AK, Meisterknecht J, Golombek M, Nortmann O, Riedel J, Peifer-Weiß L, Brocke-Ahmadinejad N, Schlütermann D, Stork B, Eichmann TO, Wittig I, Reichert AS. Life Sci Alliance. 2020 Aug 11;3(10):e202000711. doi: 10.26508/lsa.202000711. PMID: 32788226; PMCID: PMC7425215.

Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. EMBO Rep. 2020 Mar 4;21(3):e49776. doi: 10.15252/embr.201949776. Epub 2020 Feb 18. PMID: 32067344; PMCID: PMC7054676.

Publications 2019

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PMID: 31609012; PMCID: PMC6856616.

Functional Interplay between Cristae Biogenesis, Mitochondrial Dynamics and Mitochondrial DNA Integrity. Kondadi AK, Anand R, Reichert AS. Int J Mol Sci. 2019 Sep 3;20(17):4311. doi: 10.3390/ijms20174311. PMID: 31484398; PMCID: PMC6747513.