Publications

Publications 2023

E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice. Altenhofen D, Khuong JM, Kuhn T, Lebek S, Görigk S, Kaiser K, Binsch C, Griess K, Knebel B, Belgardt BF, Cames S, Eickelschulte S, Stermann T, Rasche A, Herwig R, Weiss J, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Int J Mol Sci. 2023 Jan 3;24(1):845. doi: 10.3390/ijms24010845. PMID: 36614300; PMCID: PMC9820861.

Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus. Uhlemeyer C, Müller N, Rieck M, Kuboth J, Schlegel C, Grieß K, Dorweiler TF, Heiduschka S, Eckel J, Roden M, Lammert E, Stoffel M, Belgardt BF. Mol Metab. 2023 Jan;67:101650. doi: 10.1016/j.molmet.2022.101650. Epub 2022 Dec 5. PMID: 36470401

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. Nat Cell Biol. 2023 Jan;25(1):20-29. doi: 10.1038/s41556-022-01027-2. Epub 2022 Dec 21. PMID: 36543979

Publications 2022

Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. Pafili K, Kahl S, Mastrototaro L, Strassburger K, Pesta D, Herder C, Pützer J, Dewidar B, Hendlinger M, Granata C, Saatmann N, Yavas A, Gancheva S, Heilmann G, Esposito I, Schlensak M, Roden M. Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease. J Hepatol. 2022 Dec;77(6):1504-1514. doi: 10.1016/j.jhep.2022.08.010. Epub 2022 Aug 19. PMID: 35988689.

Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise. Minafra AR, Chadt A, Rafii P, Al-Hasani H, Behnke K and Scheller J. Front. Endocrinol. 2022 Oct 27:1028808. doi: 10.3389/fendo.2022.1028808

Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene. Kuhn T, Kaiser K, Lebek S, Altenhofen D, Knebel B, Herwig R, Rasche A, Pelligra A, Görigk S, Khuong JM, Vogel H, Schürmann A, Blüher M, Chadt A, Al-Hasani H. Hum Mol Genet. 2022 Jul 7:ddac150. doi: 10.1093/hmg/ddac150. Epub ahead of print. PMID: 35796564.

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes. Görigk S, Ouwens DM, Kuhn T, Altenhofen D, Binsch C, Damen M, Khuong JM, Kaiser K, Knebel B, Vogel H, Schürmann A, Chadt A, Al-Hasani H. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159153. doi: 10.1016/j.bbalip.2022.159153. Epub 2022 Mar 31.

Many ways to Rome: Exercise, cold exposure and diet – Do they all affect BAT activation and WAT browning in the same manner?
Scheel A, Espelage L, Chadt A. International Journal of Molecular Sciences. Review Article. 2022 Apr 26;23(9):4759. doi: 10.3390/ijms23094759. PMID:35563150; PMCID: PMC9103087.

Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells. Franchina DG, Kurniawan H, Grusdat M, Binsfeld C, Guerra L, Bonetti L, Soriano-Baguet L, Ewen A, Kobayashi T, Farinelle S, Minafra AR, Vandamme N, Carpentier A, Borgmann FK, Jäger C, Chen Y, Kleinewietfeld M, Vasiliou V, Mittelbronn M, Hiller K, Lang PA, Brenner D. Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells. Nat Commun. 2022 Apr 4;13(1):1789. doi: 10.1038/s41467-022-29426-x. PMID: 35379825; PMCID: PMC8980022.

Publications 2021

Contraction-Mediated Glucose Transport in Skeletal Muscle is Regulated by a Framework of AMPK, TBC1D1/4 and Rac1.
de Wendt C, Espelage L, Eickelschulte S, Springer C, Toska L, Scheel A, Bedou AD, Benninghoff T, Cames S, Stermann T, Chadt A, Al-Hasani H. Diabetes. 2021 Sep 24:db210587. doi: 10.2337/db21-0587. Online ahead of print.PMID: 34561225